Folding and Unfolding Mechanism of Designed Ankyrin Repeat Proteins

The 'protein folding problem', i.e. understanding the detailed steps of the protein folding pathways is one of the most challenging topics in biochemistry. Combining theoretical with experimental research became indispensable for the investigation of the mechanisms in protein folding reactions. Here, the biophysical characterization of designed ankyrin repeat (AR) proteins and the analysis of the experimental data by theoretical models are presented. Repeat proteins comprise repeating structural units that form linear multirepeat arrays. The non-globular elongated structure distinguishes them fundamentally from most studied proteins and makes repeat proteins interesting for folding studies. In a previous work, a full-consensus ankyrin repeat had been designed. Such an idealized ankyrin repeat served as a model repeat to study the folding mechanism of ankyrin repeat proteins.

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Artikelnummer 9783838105062
Produkttyp Buch
Preis 71,00 CHF
Verfügbarkeit Lieferbar
Einband Kartonierter Einband (Kt)
Meldetext Folgt in ca. 10 Arbeitstagen
Autor Wetzel, Svava Kim
Verlag Südwestdeutscher Verlag für Hochschulschriften AG Co. KG
Weight 0,0
Erscheinungsjahr 20150726
Seitenangabe 104
Sprache ger
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