Artikelnummer | 9783836495554 |
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Produkttyp | Buch |
Preis | 82,00 CHF |
Verfügbarkeit | Lieferbar |
Einband | Kartonierter Einband (Kt) |
Meldetext | Folgt in ca. 5 Arbeitstagen |
Autor | Gabler, Maximilian |
Verlag | VDM Verlag Dr. Müller e.K. |
Weight | 0,0 |
Erscheinungsjahr | 2013 |
Seitenangabe | 132 |
Sprache | ger |
Anzahl der Bewertungen | 0 |
DNA Replicons Buchkatalog
In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose than a conventional DNA vaccine. DNA replicon doses as low as 10 ng significantly prevented from IgE induction by subcutaneous protein sensitization. Furthermore, in a therapeutic approach with the same construct, DNA replicons balanced an ongoing allergic response. These data were confirmed with a DNA replicon encoding the clinically relevant timothy grass pollen allergen Phl p 5. In addition, lung pathology could be prevented by pre-vaccination with DNA replicons as measured by the magnitude of eosinophilia, goblet cell hyperplasia, IL-5 production and proliferation of endothelial cells.
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