Parameters of intrathymic regulatory T cell differentiation
The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario. We found that upon exposure of monoclonal T ...