In vitro test systems for glucocorticoid-induced skin atr...
Topical glucocorticoids (GCs) are anti-inflammatory effective but limited by their side effects, in particular by the induction of skin atrophy. Thus, determining the atrophogenicity of compounds is important. This study aimed to establish according invitro models. A combination of different cellular assays with markers related to collagen metabolism and epidermal thickness was investigated using standard GCs. A GC-dependent regulation of ...